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Presented by: Dr. Jörg Fritz - Associate Professor, McGill University, and Dr. Ciriaco Piccirillo - Professor, McGill University
Date: April 20, 2022

A deeper understanding of the molecular determinants that drive humoral responses to coronaviruses, and in particular severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is critical for improving and developing diagnostics, therapies and vaccines. Moreover, viral variants have the potential of mutating key antigens in a manner that alters the ability of the immune system to detect and clear infections.

In this webinar, Dr. Fritz and Dr. Piccirillo discuss their study in which they applied a deep serological profiling strategy coupled with an integrated, computational framework for the analysis of SARS-CoV-2 humoral immune responses of asymptomatic or recovered COVID-19-positive patients relative to COVID-19-negative patients.


Topics covered

  • Use of PEPperCHIP® Peptide Microarrays to identify SARS-CoV-2 epitopes in COVID-19-positive patients
  • Evaluation of fine immunological properties of detected SARS-CoV-2 epitopes
  • Correlation of evolutionary and structural properties of epitopes using an integrated computational pipeline
  • Evolutionary profiling of epitopes and the differences across proteins, waves and SARS-CoV-2 variants
  • Analysis of emergence patterns of epitope mutations and their implications for SARS-CoV-2 immune evasion


About the presenters

Jörg H. Fritz (NPI) is Associate Professor in the Department of Microbiology and Immunology at McGill University and a member of the McGill Research Center on Complex Traits (MRCCT), a center dedicated to finding new targets for intervention in infectious and inflammatory diseases. His research led to the development of the novel vaccine adjuvant IC31 with Intercell AG/Valneva, currently in clinical trials. The research group of Dr. Fritz investigates cellular and molecular mechanisms of innate and adaptive immunity at mucosal surfaces. His research program puts a particular focus on understanding how innate immunity and antigen-specific T and B cell responses are shaped and regulated by innate lymphoid cells (ILC) during pulmonary and intestinal infectious or environmental challenges.

Ciriaco A. Piccirillo, Professor in the Department of Microbiology at McGill University, senior scientist at the Research Institute of the McGill University Health Centre (RI-MUHC), and a member of the McGill Research Center on Complex Traits (MRCCT). He leads an internationally recognized research program which focuses on the regulation of T cell responses mediated by Foxp3+ regulatory T cells in autoimmune, infectious and inflammatory diseases. His research is responsible for many seminal and pioneering studies on the biology and function of Foxp3+ regulatory T cells in a variety of animal models, non-human primates and humans. His current research program makes use of a variety of mouse models and in human subjects to monitor and characterize the development and functional dynamics of regulatory T cell function in lymphoid and non-lymphoid tissues in various inflammatory settings. His research program also focuses on the development of novel immunotherapeutic strategies to monitor and manipulate Foxp3+ regulatory T cells function and ultimately modulate immune responses in infectious, autoimmune and inflammatory disorders, cancers or immunodeficiencies.

Webinar: Selection for immune evasion in SARS-CoV-2