The invention relates to a method for identifying markers for systemic sclerosis (scleroderma, SSc) and to the markers identified by means of said method, which can differentiate between SSc and other autoimmune diseases and between different SSc sub-groups. The invention also relates to panels, diagnostic means, and test kits which comprise said markers and to the use and application thereof, for example for the diagnosis, prognosis, and therapy control for SSc. The invention further relates to methods for screening and validating active ingredients for use in SSc sub-groups.
