We updated our PEPperCHIP® Autoimmunity Microarray based on new entries in the Immune Epitope Database. The new PEPperCHIP® Autoimmune Epitope Microarray 2.0 now covers 3,359 linear autoimmune epitopes including 192 citrullinated peptides as well as the corresponding arginine variants. The IEDB-derived epitopes correlate with a variety of autoimmune diseases including Crohn’s disease, diabetes mellitus, multiple sclerosis, rheumatoid arthritis, Sjögren’s syndrome, systemic lupus erythematosus, vitiligo and many more.
Numerous research institutes, biotech and pharma companies meanwhile successfully applied the PEPperCHIP® Autoimmunity Microarray to e.g. disclose differential antibody responses of autoimmune patient groups or to discover new diagnostic markers.
"Through the help of researchers at PEPperPRINT, we have identified several important lupus and arthritis associated autoantigen epitopes in a complex mouse model of autoimmunity. The comprehensive database behind these epitopes has enabled us to identify that these epitopes are mostly associated with nucleosomal or ribonucleosomal proteins. The PEPperCHIP epitope analysis has now helped us to move on to determine the immuno pathogenic mechanisms in our autoimmune mice."
(Hui-Chen Hsu, PhD, Ass. Prof., Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham)
For more information on the epitope content of the new PEPperCHIP® Autoimmune Epitope Microarray 2.0, please download the material data sheet as well as the microarray layout scheme on the product website.